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Adenovirus helper-free system for producing recombinant AAV virions lacking oncogenic sequences
Adenovirus helper-free system for producing recombinant AAV virions lacking oncogenic sequences
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机译:用于生产缺乏致癌序列的重组AAV病毒体的无腺病毒无辅助系统
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摘要
Composition and methods are provided for producing recombinant AAV ("rAAV") in the absence of helper virus, such as adenovirus. The compositions provide the accessory functions necessary for supporting rAAV virion production in host cells. In certain embodiments, the accessory functions are provided by vectors comprising nucleotide sequences from an adenoviral E4 region which lack the putatively oncogenic E4 ORF 6 coding region. The present invention also includes host cells transfected by the claimed accessory function vectors, methods of using such vectors, and rAAV virions produced by such methods.
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