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Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease

机译:乙酰水杨酸和微量营养素补充剂,用于营养流失和冠心病

摘要

The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin- mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process. Moreover, certain modular formulations of the present invention incorporate both antioxidants and acetylsalicylic acid (aspirin) as a single preventive modality. Such a combination of antioxidants and aspirin is believed to act to prevent oxidation of low density lipoproteins within coronary arterial walls and to cause platelet deagluttination thereby inhibiting thrombus formation. The benefit of preventing these two major processes is believed to reduce the risk of coronary heart disease.
机译:本发明总体上涉及公共卫生领域,包括预防和治疗冠心病,冠心病目前是美国人群中的第一死亡原因。更具体地,本发明涉及由7种不同的模块组成的多种维生素和矿物质补充的总模块系统,该模块通过确保足够的微量营养素摄入来改善公共卫生,这些微量营养素用于预防疾病并保护其免受例如生活方式因素造成的营养损失和营养缺乏和常见的饮食习惯不足。如本文通篇所使用的,模块被定义为针对特定目标人群的维生素-矿物质和其他促进健康的化合物的单独和不同的组合。当本发明的制剂在一个胶囊或片剂中或作为单独的模块组合时,对涉及动脉粥样硬化过程的主要致病因子发挥联合和增强作用。此外,本发明的某些模块化制剂将抗氧化剂和乙酰水杨酸(阿司匹林)两者结合为单一预防方式。据信抗氧化剂和阿司匹林的这种组合可防止冠状动脉壁内低密度脂蛋白的氧化并引起血小板脱凝,从而抑制血栓形成。认为预防这两个主要过程的益处可降低冠心病的风险。

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