Synthesis of estrogen-purine base and estrogen-mercapturate adducts and development of fluorescent probes and monoclonal antibodies to assay those adducts

摘要

Estrogen-nucleoside, estrogen-guanine and estrogen- mercapturate adducts are potential biomarkers for determining susceptibility of animals to a number of estrogen related cancers. These adducts may be used as biomarkers for determining risk of estrogen- induced cancers. A linker chemistry has been devised to couple these adducts to protein for production of immunogens, required for production of specific monoclonal antibodies.