Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth

摘要

A process for the preparation of &bgr;-lapachone and dunnione derivatives of formulae I and II ##STR1## wherein, the a solution of lawsone in dimethylsufoxide at a temperature of -78° C. or less is reacted with lithium hydride forming the lithium salt of lawsone; alkylating the lithium salt with an allyl halide; and cyclizing the C- alkylated lawsone derivative.