首页>
外国专利>
Cyclin/CDK associated proteins, and uses related thereto
Cyclin/CDK associated proteins, and uses related thereto
展开▼
机译:细胞周期蛋白/ CDK相关蛋白及其相关用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the discovery in mammalian cells, particularly human cells, of novel S-phase kinase associated proteins, p19 and p45, referred to herein as "Skp". As described herein, these proteins are components of the tumor cell-specific cyclin A/CDK2 complex and function to facilitate DNA replication. Interference with p45 function in vivo prevented entry into S-phase in both normal and transformed cells. Binding data indicated that p45 and p19 associate with each other in a binary complex. Moreover, p45 is required for p19 binding to cyclin A/CDK2.
展开▼