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New regulation cancer Characteristic antibiotic
New regulation cancer Characteristic antibiotic
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机译：新法规癌症特征性抗生素
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摘要
PROBLEM TO BE SOLVED: To obtain the subject material capable of inhibiting the propagation of mouse leukemia cells in a low concentration and useful as a carcinostatic agent, or the like by culturing a microorganism belonging to the genus Streptomyces and having a function of producing the antibiotic material having the carcinostatic activity. ;SOLUTION: This new carcinostatic antibiotic material 14A5 has the following physicochemical properties. Melting point; 155-160°C, [α]20D; +258° (C-0.01, CHCl3), mass spectrum (FAB-MS)=m/z 510 (M+H)+, UV spectrum [λmax, nm (E11cm)], 90% MeOH; 492, (293), 293 (160), 254 (461), 234 (813). The antibiotic material 14A5 inhibits the propagation of mouse leukemia cells in a low concentration, is useful as a carcinostatic agent, and is obtained by culturing a microorganism belonging to the genus Streptomyces and having a function of producing the antibiotic material 14A5, and collecting the antibiotic material therefrom.;COPYRIGHT: (C)1999,JPO
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机译：解决的问题：通过培养属于链霉菌属并具有产生抗生素功能的微生物来获得能够以低浓度抑制小鼠白血病细胞的增殖并用作抗癌剂等的主题材料。具有抗癌活性的材料。 ;解决方案：这种新的抗癌性抗生素材料14A5具有以下理化特性。熔点; 155-160℃，[α] 20 D; + 258°（C-0.01，CHCl 3 ），质谱（FAB-MS）= m / z 510（M + H） + ，紫外光谱[λmax， nm（E 1 1 cm ）]，90％甲醇; 492，（293），293（160），254（461），234（813）。抗生素材料14A5以低浓度抑制小鼠白血病细胞的增殖，可用作抗癌剂，并且通过培养属于链霉菌属的具有生产抗生素材料14A5的功能的微生物并收集抗生素而获得。版权归：（C）1999，JPO
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