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Conjugated antibody of human subgroup IV L chains capable of binding to TAG-72
Conjugated antibody of human subgroup IV L chains capable of binding to TAG-72
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机译:能够与TAG-72结合的人IV亚组L链缀合抗体
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摘要
This invention concerns a subset of composite Hum4 VL, VHαTAG antibody with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) VL segments derived from the human subgroup IV germline gene and (2) a VH segment which is capable of combining with the VL to form a three dimensional structure having the ability to bind TAG-72. in vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.
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