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HARD GELATIN CAPSULE AGENT HAVING IMPROVED DISSOLUTION PROPERTY
HARD GELATIN CAPSULE AGENT HAVING IMPROVED DISSOLUTION PROPERTY
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机译:硬明胶胶囊剂的溶出度得到改善
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PROBLEM TO BE SOLVED: To suppress the insolubilization of gelatin and improve the dissolution property of an active component by including aminoacetic acid in the agent filled in a capsule. ;SOLUTION: Aminoacetic acid is included in an agent filled in a hard gelatin capsule. The amount of the aminoacetic acid is preferably 0.5-30 wt.% based on the shell of the capsule. The capsule agent preferably contains a condensed imidazopyridine derivative, etc., such as 2-(isoxazol-3-yl)-1,6,7,9- tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine as an active pharmaceutical component in an amount of 0.1-40 wt.% based on the whole capsule agent and 5-150 wt.% based on the shell of the capsule. The capsule shell is preferably incorporated with 30-60 wt.% of a disintegration agent (e.g. carboxymethyl cellulose).;COPYRIGHT: (C)2000,JPO
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