ANTI-MRSA ANTIBIOTIC

摘要

PROBLEM TO BE SOLVED: To obtain a new compound useful as an antibiotic effective for infec tious diseases caused by various pathogenic bacteria including multiple drug- resistant bacteria of Staphylococcus aureus. ;SOLUTION: This new compound is such one as to be a white powdery acidic substance, soluble in chloroform and ethyl acetate and insoluble in hexane. This compound has such physicochemical properties as to have a specific rotatory power of [α]D22=-45±5° (c=1.0, DMSO), molecular weight of FAB-MS m/z 1110(M+H), have the main absorption peaks in its ultraviolet absorption spectrum at 213, 278-283, 310-320 nm in methanol, and have 1H-NMR spectrum (400 MHz, d6-DMSO) as shown in the figure. This compound is obtained by culturing bactera capable of producing the above-mentioned compound and belonging to the genus Kineosuporia [e.g. Kineosporia sp. AP11158(FERM BP-6653)] by shaking culture or the like in a liquid medium, and then, separating the compound from the cultured product.;COPYRIGHT: (C)2000,JPO