Compounds mercaptoacetilamino - 1.5 - 3 - oxo - Azepan useful as inhibitors of Matrix Metalloproteinases,Pharmaceutical Composition and uses for the manufacture of Medicines for the treatment of diseases that respond to inhibition of Matrix Metalloproteinases

摘要

Described are compounds of the formula (i), where R1 is alkyl group C1 - C6, a W - M - (CH2), or a group Q - Z - (CH2) where W is phthalimido m; Z is a link or Oxy, NR6 NR6, C (OR), (OR), nr6c NHC (NR6), OC (NR6),HNC (OR) or so2nr6; Q is Hydrogen, or ung and N - (CH2) where Hydrogen is N - aryl - and C6, C9 C10, heteroariloc3 -, - C (o) - or6, n 2 (r6), morpholino, pirrolidino piperidino, R2 is alkyl or isoindolilo; C1 C4A Group - (CH2) P - heteroaryl C3 C9, or a Group (CH2) P - ar1donde AR1 is phenyl or substituted naftiloopc ionalmente; R3 is Hydrogen, C1 to C6 alkyl -, - ch2sch2nhcoch3 Group, a - (CH2) n -,A Group - (CH2) M - B or - CH2 - Group D - R7 where C6 C10 is aryl, heteroaryl or C3 C9, Cyclohexyl; b - N (R7) 2, guanidine, nitroguanidino,- C (o) - C (o) or or6 NR6; and D is Oxy or Uncle; R4 is Hydrogen or a Group - (CH2) M - S (o) x 2 (r6); R5 is Hydrogen,C1 - C6 alkyl R4 and R5 or taken along with the nitrogen Atom to which they are ancladosforman piperidino, pirrolidino, or isoindolilo; eshidrogeno alq uilo R6 and R7 is C1 - C6; Hydrogen or c1-c4 alkyl,Or a Group - (CH2) where p ar ar is optionally substituted phenyl onaftilo; R8 is Hydrogen, - C (o) R7, a group C (o) - (CH2) Q - K - A - S - group G, where K is selected from the group formed poramino,Uilamino Alq, fenilalquilamino, Heterocycles, and substituted Heterocycles; g is chosen from the group consisting of formula (ii); or otrosalquilo R12 to R16 are between - (CH2) V1 is pair; or,O or NH; V2 is n or CH; V3 is a link or - C (o) - (CH2); V4 is - W -, r, S, nr7 or CN (R11); X and x are each independientementech or a Salt, N;Stereoisomer or pharmaceutically acceptable hydrate.Derivatives are included in a Pharmaceutical Composition and use in produce Medicines to treat diseases that respond to inhibition of metal Protein of the Matrix.