Benzotiazepin - 1.1 - 1.4 - dioxides lipid-lowering agents, Pharmaceutical compositions,Use of these compounds for the manufacture of Drugs and Methods for preparing these compounds and Intermediate compounds for their Preparation

摘要

1,4-benzodiazepine-1,1-nitrous oxide including formula (I)en la que R1 es un grupo alquilo de C1-6 de cadena lineal R2 es un grupo alquilo deC1-6 de cadena lineal R3 es hidrogeno o un grupo OR11 en el que R11 es hidrogeno un grupoalquilo de C1-6 o alquilcarbonilo de C1- O (CH2) pNR12R13 and O (CH2) pN + R12R14 where p is an integer from 1-4; n is an integer from 0-3 and R12, R13, R14 and R15 are independently selected from hydrogen and optionally substituted C1-6alkyl; R7 is a group in formula (II) in which the hydroxyl groups can be substituted with acetyl or benzyl, or formula: -C1-C6 alkyl-R17 in which the alkyl group can be substituted with one or more hydroxyl groups ; R16 is -COOH or -CH2-OH; R17 is H, -OH, -NH2, -COOH or COOR1 8; R18 is (C1-C4) alkyl or -NH-(C1-C4) alkyl;X is -NH-U-O.R9 and R10 are the same or different, each of which is a C1-6 hydrogen or hydrocarbon; its salts, solutions and physiological functional derivatives; its compounds are the same as the contained compounds, and are used in medicine, especially for the treatment of mammary gland hormone and the state of high-fat plasma, such as hydrate, Prepare for your programs and new computers.