首页> 外国专利> Composition consisting essentially of GBS toxin (beta hemolytic Streptococcus Group B), Pharmaceutical composition, metodode purification of the toxin.ToXin obtained by Said method and use of this toxin in preparing Pharmaceutical compositions

Composition consisting essentially of GBS toxin (beta hemolytic Streptococcus Group B), Pharmaceutical composition, metodode purification of the toxin.ToXin obtained by Said method and use of this toxin in preparing Pharmaceutical compositions

机译:基本上由GBS毒素组成的组合物(β溶血性链球菌B组),药物组合物,该毒素的方法进行纯化。通过Said方法获得的毒素及其在制备药物组合物中的用途

摘要

A method for PURIFYING A toxin (polysaccharide) of beta hemolytic Streptococcus Group B (GBS) includes a contact from bacterial fermentation with a Resin ChromatographyHydrophobic Interaction (HIC). Additional steps may include a confenol / Saline Extraction and Ion Exchange Chromatography.The Method results in a product that has a very high purity.The product of lapurificacion provides a composition that is useful for both Research and therapeutic purposes.Additionally includes a composicionnueva has higher Purity and Biological activity in comparison with the previously known methods and the use of this toxin to prepararcomposicPharmaceutical ions.
机译:纯化β溶血性链球菌B组(GBS)的毒素(多糖)的方法包括细菌发酵与树脂色谱-疏水相互作用(HIC)的接触。其他步骤可能包括香酚/盐提取和离子交换色谱法。该方法产生的产品具有很高的纯度。拉普拉硫磷的产品提供了既可用于研究目的又可用于治疗目的的组合物。与以前已知的方法以及使用该毒素制备前合成药物离子相比,具有更高的纯度和生物活性。

著录项

  • 公开/公告号AR011238A1

    专利类型

  • 公开/公告日2000-08-16

    原文格式PDF

  • 申请/专利权人 VANDERBILT UNIVERSITY;

    申请/专利号AR1997P104505

  • 发明设计人

    申请日1997-09-30

  • 分类号C12P1/04;C12P19/04;C07H5/00;A61K31/715;C12P1/04;C12R1/46;

  • 国家 AR

  • 入库时间 2022-08-22 01:57:29

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