A composition comprising Trehalose Lyophilized Liposomes and Lipid which has Incorporated a Biologically Active principle and a procedure for lyophilization of a.N comprising Trehalose and Lipid Liposomes

摘要

A soluble compound composed of trihalogens and lipolipids, in which a biological activity principle is added, wherein the biological activity principle is very insoluble in water, the relationship between trihalogens / lipids of fish; / = 1.5, the whole trihalogens are absorbed to the external parts of formed fats. Before gonorrhea. It is better to choose the biological activity principle containing 1 - [(2,4-dichlorophenyl) methyl] - 1h-indazol-3-carboxyl (longanamine) acid, which is a highly insoluble water,melatonin, cyclosporin A and 2 - [(1-benzyl-1H-3-indazolyl) methoxy] -2-methylpropanoic acid, (Bindarit). Preferably the lipids are selected from the group or comprising phosphoglycerides, glycerides, diglycerides, triglycerides, phospholipids, galactosyl and glucosyl lipids, cholesterol and its derivatives, sphingolipids and mixtures thereof. The average size of the liposomes can be understood between 5 0 and 250 nm. A procedure for lyophilization of a composition comprising both chalky and lipid liposomes, in which a biologically active principle has been incorporated,donde a) de 0 2 a 1 5 partes en peso detrehalosa seagregan a cada parte en peso de los l pidos de una composicion de liposomas acuosa en la cual el tamano promedio de los liposomas queda comprendidoentre 50 y 250 nm comprendiendo dichos liposomas un principio biologicamente