首页> 外国专利> Compounds derived from 3 - (pyrrolidin-3-yl) - 1,3,4-oxadiazol-2 (3H) - One, possibly in the form of Pure Optical isomers or mixture of isomers, Process for preparing them,Medicine of said compound and Pharmaceutical composition containing Said Compound.

Compounds derived from 3 - (pyrrolidin-3-yl) - 1,3,4-oxadiazol-2 (3H) - One, possibly in the form of Pure Optical isomers or mixture of isomers, Process for preparing them,Medicine of said compound and Pharmaceutical composition containing Said Compound.

机译:衍生自3-(吡咯烷-3-基)-1,3,4-恶二唑-2(3H)的化合物,可能为纯旋光异构体或异构体混合物的形式,其制备方法,所述化合物的药物和含有所述化合物的药物组合物。

摘要

3 - (pirrolidin-3-il) - 1,3,4-oxadiazol-2 (3H) compounds may exist in the form of pure optical isomers or mixtures of isomers. According to the general formula I, R1 represents a hydrogen atom or a grupop1-4 tar or c3-7 cyclopentanediol, X1 represents a hydrogen or halogen atom or a C1-4 alcox group, Or1 and X1 together represent a formula group - och2o,-O (CH2) 2-,-O (CH2) 3 -, - O (CH2) 2 O- or -O (CH2) 3 O-,X2 is a hydrogen atom, an amino group or a general-nhco2r formula group, R represents a C1-4 tar group or a phenyl C1-2 tar group, X3 represents a hydrogen or halogenated atom, R2 represents a hydrogen atom, or a C1-6 tar group, C1-4 tar or [(4-dimethylamino) piperidin-1-ilcarbonil] c2-4 tar, in the state of base or acid-dependent sa preparation procedure, including formula I and drug synthesis containing formula I compound.
机译:3-(吡咯烷-3-1-1)-1,3,4-恶二唑-2(3H)化合物可以纯旋光异构体或异构体混合物的形式存在。根据通式I,R1代表氢原子或grupop1-4焦油或c3-7环戊二醇,X1代表氢或卤素原子或C1-4烷氧基,Or1和X1一起代表式基团-och2o, -O(CH2)2-,-O(CH2)3-,-O(CH2)2 O-或-O(CH2)3 O-,X2是氢原子,氨基或一般的nhco2r式基团R 1表示碳原子数为1〜4的伯基或苯基的碳原子数为1〜2的伯基,X3为氢或卤原子,R2为氢原子或碳数为1〜6的伯基,C1-4的伯基或[(4-二甲基氨基)哌啶-1-基[ilcarbil] c2-4焦油,呈碱或酸依赖性盐的状态;制备方法包括包括式Ⅰ的化合物和含有式Ⅰ化合物的药物合成。

著录项

  • 公开/公告号AR012657A1

    专利类型

  • 公开/公告日2000-11-08

    原文格式PDF

  • 申请/专利权人 SYNTHELABO;

    申请/专利号AR1998P102080

  • 发明设计人

    申请日1998-05-05

  • 分类号C07D413/04;C07D413/14;A61K31/41;A61K31/445;

  • 国家 AR

  • 入库时间 2022-08-22 01:57:31

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