N-HYDROXY-2-(ALKYL-, ARYL- OR HETEROARYL-, SULPHANYL-, SULPHYNYL- OR SULPHONYL-)-3-SUBSTITUTED ALKYL-, ARYL- OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS

摘要

The invention relates to non-peptide matric metalloproteinase (MMP) inhibitors and TNF- conversion enzyme (TACE) with low molecular weight. They are administered for the treatment of arthritis, tumour metastases, tissue ulcerations, wrong wound healing, paradontosis diseases, osteal diseases, insulin-independent diabetes and HIV infections. The compounds have the formula where R2 and R3 form heterocyclic ring and A is S, S(O) or S(O)2, and R3 and R4 have the meaning listed in the description. 19 claims