PYRIDO/2,3-d/PYRIMIDINES FOR THE INHIBITION OF CELLULAR PROLIFERATION CAUSED BY PROTEINETHYROSINEKINASE

摘要

The invention relates to 6-aryl-pyrido/2,3-d/pyrimidine-7-imines, 7-ons and 7-thions with the formula where the substituents of R1 & R2 have the meanings indicated in the description. The compounds are inhibitors of proteinthyrosikinase and for this reason they are useful for the treatment of cellular proliferation to which they are mediators. They are particularly useful in the treatment of cancer, atherosclerosis, restenosis and psoriasis. 12 claims