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NOVEL SYNTHETIC PEPTIDE, LUNG SURFACTANT CONTAINING THE SAME, AND REMEDY FOR RESPIRATORY DISTRESS
NOVEL SYNTHETIC PEPTIDE, LUNG SURFACTANT CONTAINING THE SAME, AND REMEDY FOR RESPIRATORY DISTRESS
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机译:新型合成肽,含有相同表面活性剂的肺表面活性剂和呼吸道疾病的补救措施
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摘要
The invention relates to a synthetic peptide, containing the following sequence: Xaa-Pro-Val-Xbb-Xcc-Lys-Arg-W, (wherein Xaa is absent or represents Cys or Ser; Xbb represents His or Asn; Xcc represents Leu or Ile; and W represents a hydrophobic peptide portion); an intermediate for producing the peptide; a process for producing the peptide; a lung surfactant comprising the peptide and a lipid mixture; and a remedy for respiratory distress syndrome containing the surfactant at the active ingredient. The peptide is easy to isolate and purify and suitable for mass production. As it is highly soluble in methanol and the like, it can readily be blended with a lipid mixture and is suited for the preparation of a lung surfactant. As the lung surfactant has a good suspensibility and a potent surface activity, it is useful as a remedy for respiratory distress syndrome. 8 claims
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