Process for the preparation of trans - 3 - acid ester substituted glicìdico optically active.

摘要

Process for the preparation of acid ester trans - 3 - substituu00ecdo glicu00ecdico optically active.A process for the preparation of a compound of the ester acid trans - 3 - substituted - optically active glycidyl of formula (I), in which the ring a is a benzene ring replaced or not replaced.And R ^ 1 ^ is a residue of ester, which comprises: preparation of a solution or an optical isomer (a) and the other optical isomer (b) ester compound (I),Both of which are optical isomers due to the asymmetric carbons in positions 2 and 3, and an ester compound (b) which is different from the isomer (b) only of the residue of ester R ^ 1 ^.Crystallization of the optical isomer (a) of the solution to the point at which the optical isomer (a) is crystallized without precipitation of the optical isomer (b) due to the presence of the ester compound (B ') while the isu00f3mEro optical (b) precipitated the ester compound (B ') was not present, and isolation of the crystals of optical isomer (a)At a desired optical isomer (a) can be obtained with high purity and high yield such that the desired isomer can be crystallized until the concentration of the desired isomer in the liquid motherBe very low if compared with conventional processes.