Antigenic fusion protein carrying galoc epitopes 1.3 gal

摘要

"ANTIGENIC FUSION PROTEIN CARRYING GAL 244 EPIPTOS 1, 3GAL". The fusion protein according to the invention can be comprised of a part of highly glycosylated mucin, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IG G. The fusion protein according to the invention is preferably used as an absorber to prevent hyperacute rejection of a xenotransplant, such as pig tissue or organ transplanted to a human patient. In addition, the invention relates to a process for preventing hyperacute rejection reaction in a patient who must receive a xenotransplant.