Lipossomais vectors of princìpios assets, the preparation process of vectors powders, pharmaceutical composition, and dispersion of liposomes with internal nuclei gelatinizados

摘要

"Lipossomais vectors of princu00ecpios active preparation process of vectors powders, pharmaceutical composition, and,The dispersion of liposomes with internal core gelatinizados "vectors lipossomais stable in the form of active principles.And, more particularly, active ingredients susceptible to digestive degradation and / or plasma, such as proteins, as well as its application as a medicine.These vectors lipossomais of active principles consist of a powder composition which consists essentially of liposome comprising a lipid phase unilamelares foreign consEstablished lipid class 4 (phospholipid) possibly associated with substances of class 2.Substances of class 3 and / or substances of class 5 and a core internal aqueous consists mainly of a mixture of at least two agents gelatinizantes non polymerisable G1 and G2.The different and the point of the phase transition gel sol is greater than or equal to 37 u00b0 C,G1 being a gelatinizante agent selected among the gelatin and the carrageenanos and G2 sense selected among the carrageenanos having properties different from carrageenanos selected for G1And celluloses, which liposomes have a diameter between 20 nm and 1 mm, preferably between 20 nm and 500 nm.This composition is presented in the form of units of particles having a average diameter between 10 mm and 1000 mm, formed of one or more of these liposomes.Surrounded by a sheath is selected among the group consisting of an aqueous gel thermo reversible dehydrated identical to the aqueous gel of the inner core, dextrin or a mixture of these.In such a way that he understands, an average of 10 ^ 16 ^ 10 ^ 18 ^ liposomes / g of powder and at least one active principle including, as appropriate, in the inner core.,In the lipid phase foreign.