Specific mamaglobin vaccine, process to treat a patient with a tumor that expresses mamaglobin, and isolated and purified polypeptide

摘要

"MAMAGLOBIN SPECIFIC VACCINE, PROCESS TO TREAT A PATIENT WITH A TUMOR THAT EXPRESSES MAMAGLOBIN, AND, ISOLATED AND PURIFIED POLYPEPTIDE" A purified and isolated DNA sequence and the encoded protein secreted specifically by the breasts, mamaglobin, are presented. Methods for detecting breast cancer based on overexpression and secretion of mammaglobin by breast cancer cells are also presented. The methods detect and / or quantify the presence of mammaglobin or the mRNA that encodes mammaglobin. Immunotherapy-based methods of treating a breast cancer patient with a tumor expressing mammaglobin are also presented. The methods involve the use of mammaglobin antigens to induce a humoral and / or cell-mediated immune response against the tumor.