Processes for expressing a heterologous sequence in a tumor cell, and for treating cancer in a subject, vector for expressing a sequence in a tumor cell, and, host cell

摘要

"PROCESSES TO EXPRESS A HETEROLOGICAL SEQUENCE IN A TUMOR CELL, AND TO TREAT CANCER IN A SUBJECT, VECTOR TO EXPRESS A SEQUENCE IN A TUMOR CELL, AND, HOST CELL". The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of transcriptional regulatory sequences. Particularly preferred promoters include the H19 regulatory sequences, the IGF-1 promoter and the IGF-2 promoters P3 and P4. The invention provides expression constructs and processes for administering those expression constructs. The compositions and processes of the invention are useful in the treatment of cancer.