'conjugate vaccine for moraxella catarrhalis, pharmaceutical composition, lipooligosaccharide, and, processes for preventing otitis media caused by infection with moraxella catarrhalis in a mammal, detoxifying lipooligosaccharide (los) isolated from moraxella catarrhalis, and preparing a vaccine for conjugated against moraxella catarrhalis '

摘要

'' CONJUGATE VACCINE FOR MORAXELLA CATARRHALIS, PHARMACEUTICAL COMPOSITION, LIPOOLIGOSACARIMOUS, AND, PREVENTION PROCESSES OF MEDIUM OTITIS CAUSED BY THE INFECTION WITH MORAXELLA CATARRHALIS IN A MAMMALOUS DE LACOXA, DE MACAO MOSACO, DE MACHOSCOPE CONJUGATE AGAINST MORAXELLA CATARRHALIS '' A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce an oligosaccharide OS) detoxified, which is linked in an immunogenic vehicle. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.