Carboxylic acid derivative, use of it, combination, and drug preparation for oral, parenteral and intra-parenteral administration

摘要

"CARBOXYLIC ACID DERIVATIVE, USE OF THE SAME, COMBINATION, AND DRUG PREPARATION FOR ORAL, PARENTAL AND INTRA-PARENTAL ADMINISTRATION" The invention relates to carboxylic acid derivatives of formula (I) in which the substituents have the following meanings ; R¹ = tetrazole or a group (1): R = an OR ^ 7 ^ radical (2), (3): a 5-membered heteroaromatic linked by a nitrogen atom such as pyrrolyl, pyrazolyl, imidazolyl and trizolyl; R², R³ = hydrogen, hydroxy, NH ~ 2 ~, NH (C ~ 1 ~ -C ~ 4 ~ -alkyl), N (C ~ 1 ~ -C ~ 4 ~ -alkyl) ~ 2, ~ halogen, C ~ 1 ~ -C ~ 4 ~ -alkyl, C ~ 2 ~ -C ~ 4 ~ -alkenyl, C ~ 2 ~ -C ~ 4 ~ -alkynyl, C ~ 1 ~ -C ~ 4 ~ -hydroxyalkyl, C ~ 1 ~ -C ~ 4 ~ -alkoxy, C ~ 1 ~ -C ~ 4 ~ -haloalkyl, C ~ 1 ~ -C ~ 4 ~ -alkoxy, C ~ 1 ~ -C ~ 4 ~ -haloalkoxy, or C ~ 1 ~ - C-4-alkylthio; X = halogen, C ~ 1 ~ -C ~ 4 ~ -haloalkyl, hydroxy, R ^ 4 ^ and R ^ 5 ^ = phenyl or naphthyl, C ~ 3 ~ -C ~ 7 ~ -cycloalkyl, phenyl or naphthyl which are bonded in the ortho position by a direct bond, a methylene, ethylene, or ethylene group, an oxygen atom, or sulfur or a SO ~ 2 ~ -NH or N-alkyl group or a 5-membered or 6-membered heteroaromatic; R ^ 6 ^ = hydrogen, phenyl or naphthyl, a five- or six-membered heteroaromatic; C ~ 1 ~ -C ~ 8 ~ alkyl, C ~ 3 ~ -C ~ 6 ~ -alkenyl, C ~ 3 ~ -C ~ 6 ~ -alkynyl or C ~ 3 ~ -C ~ 8 ~ -cycloalkyl, whereby radicals mentioned can be substituted once or many times, with the proviso that R ^ 6 ^ can only mean hydrogen if Z does not represent a single bond; Z = sulfur, oxygen or a simple bond, in addition to physiologically compatible salts and the enanciomeric-pure and diastereomeric-pure forms. The new compounds are suitable for fighting diseases, especially as endothelin antagonists.