Preparation method of naftiridona or quinolone carboxylic acid derivatives substituted in position 7 by azacicloamina acid by coupling with a 7 - halogenorespectivo SAIn addition azacicloamina acid compound, compounds are antibacterial.

摘要

Procedimientopara quinolone carboxylic acids and preparation of carboxylic acids naftindona antibacterial formual III, which has an external amino Group attached to their Substituent 7Without the use of blocking groups and subsequent Elimination in the external amino Group, which consists in contacting a compound of formula IV with a compound of formula (CH2) anh2 HR1.(g) B. In a Preferred embodiment, the naftiridona carboxylic acid is the trovafloxacina antibiotic.