Inhibitors of farnesyl Protein transferase inhibitors of proteinofarnesiltransferasa and the ocntienen nes.

摘要

The present invention is directed at the compounds of dodecenoic acid and acrylamide, which are inhibitors of protein-o-phenyltransferase and have multiplier effect: R21 is hydrogen or C1-C6 hydrocarbon; RQ ESN is 0 or 1; a es-cora,-CO2 RA-Conhra-CSRA-C (S) ORa-C (S) NHRa´,-SO2 RA,-CONRa Ra ", Ra,Ra´ and Ra "are independently C1-C6 alkyl,-(CH2) m-cycloquilo, - (CH2) m-arilo o - (CH2) m-heat arilo; each m is independent of 0-3; R1,R2 and R4 are independent C1-C6 hydrogen or tar; R3 is,-(CH2) m-heteromorphic, - (CH2) m - (CH2) m-naftilo, - (CH2) m - (heteromorphic, replaced by RB),Or C1-C6, t is 2 to 6