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Preparation applicable through vagina for maintaining healthy intravaginal bacterial flora and for prevention sexually contagious diseases

机译:通过阴道可用于维持健康的阴道内细菌菌群和预防性传染病的制剂

摘要

In the present invention there is disclosed intravaginal suppository or another type of vaginally applicable preparation such as cream, foam or ointment containing as active components at least pharmaceutically acceptable topic safe antimicrobial agent, such as agent being selected from a group comprising benzalkonium chloride, cetylpyridinium chloride, chlorohexidine gluconate and povidone iodine, imidazolidinyl urea and diazolidinyl urea, and colony of lactobacillus bacteria encapsulated in thin layer. The viable lactobacillus is contained in the suppository in encapsulated form that protects bacteria during storage of the suppository from activity of the bactericidal agent. As soon as the suppository is exposed to vaginal environment the encapsulating thin layer is sufficiently disintegrated due to the action of moisture and releases lactobacillus bacteria. The lactobacillus bacteria serve for maintaining or repeated creation of healthy flora based on the lactobacillus on vaginal wall and for secreting hydrogen peroxide and other bactericidal substances which suppress conditions of abnormal flora supporting origin of infections.
机译:在本发明中,公开了阴道内栓剂或另一种可阴道使用的制剂,例如霜剂,泡沫剂或软膏剂,其包含至少药学上可接受的局部安全的抗微生物剂作为活性成分,例如选自苯扎氯铵,十六烷基氯化吡啶鎓的试剂。 ,葡萄糖酸氯己定和聚维酮碘,咪唑烷基尿素和重氮烷基尿素,以及乳杆菌细菌的菌落包裹在薄层中。活的乳酸菌以包囊的形式包含在栓剂中,其在栓剂的储存期间保护细菌免受杀菌剂的活性。一旦将栓剂暴露于阴道环境,由于水分的作用,包封的薄层就充分崩解并释放出乳酸菌细菌。乳杆菌细菌用于维持或重复建立基于阴道壁上的乳杆菌的健康菌群,并用于分泌过氧化氢和其他杀菌物质,这些物质可抑制支持感染起源的异常菌群的状况。

著录项

  • 公开/公告号CZ286831B6

    专利类型

  • 公开/公告日2000-07-12

    原文格式PDF

  • 申请/专利权人 LAFOR LABORATORIES LIMITED;

    申请/专利号CZ19960001602

  • 发明设计人 FORD LARRY C.;

    申请日1994-12-02

  • 分类号A61K9/48;A61K9/02;A61P31/04;A61P31/12;A61P15/18;

  • 国家 CZ

  • 入库时间 2022-08-22 01:56:52

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