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Process of adjusting polypeptide affinity to target molecule, antibody molecule, enhanced antibody, nucleic acid molecule, pharmaceutical preparation and treatment method
Process of adjusting polypeptide affinity to target molecule, antibody molecule, enhanced antibody, nucleic acid molecule, pharmaceutical preparation and treatment method
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机译:调节多肽对靶分子,抗体分子,增强抗体,核酸分子的亲和力的方法,药物制备和治疗方法
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摘要
The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
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