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CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS, THEIR PRODUCTION AND MEDICAMENT CONTAINING THEM
CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS, THEIR PRODUCTION AND MEDICAMENT CONTAINING THEM
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机译:循环GMP特异性磷酸酯酶抑制剂,其生产和含有它们的药物
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PCT No. PCT/EP96/03025 Sec. 371 Date May 15, 1998 Sec. 102(e) Date May 15, 1998 PCT Filed Jul. 11, 1996 PCT Pub. No. WO97/03985 PCT Pub. Date Feb. 6, 1997A compound having the formula (I) and solvates thereof, wherein: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen or C1-6alkyl; R2 represents the bicyclic ring which may be optionally substituted by one or more groups selected from halogen and C1-3alkyl; and R3 represents hydrogen or C1-3alkyl is disclosed. The compounds are potent and selective inhibitors of cGMP-specific PDE, and are useful in a variety of therapeutic areas where such inhibition is beneficial.
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