Bifidobacterium longum infantis in the treatment of inflammatory bowel disease

摘要

A strain of Bifidobacterium longum infantis was isolated from resected and washed human gastrointestinal tract which is capable of combating the effects of inflammatory bowel disease. This capability is maintained in the presence of physiological concentrations of human bile and human gastric juice. The capability of combating the effects of inflammatory bowel disease can be measured by measuring a reversal of a wasting disease induced in severe combined immunodeficient recipient mice (SCID) which have been administered CD4+, CD45RBhigh T cells. Two or more strains of Bifidobacterium longum infantis can be used in foodstuffs and medicaments optionally in the presence of a strain of Lactobacillus salivarius, such as Lactobacillus salivarius strain UCC 118.