Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids

摘要

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention proposes a method of synthesis of new 5-substituted pyrrolo[2,3-]pyrimidines that can be used as semiproducts for synthesis of pyrrolo[2,3-]- -pyrimidine antitumor agents or antitumor agents. Method of synthesis of the above indicated compounds of the general formula (I) where R is or OR where R - hydrogen or similar or distinct carboxy-protected groups, sign * means L-configuration at carbon atom, n= 0 or 1 and - aryl group that can be substituted, or their salts involves: a) interaction of 2,4-diamino-6-hydroxypyrimidine with haloidaldehyde of the formula (II) where Y -bromine, chlorine or iodine atom, and , R, R, n and * are indicated above; and b) optionally reaction of salt formation of reactive product of the stage a). Invention describes an additional method of synthesis of compounds of the formula (I). Synthesis is carried out in a single flask. EFFECT: improved method of synthesis. 10 cl, 9 ex