Liquid pharmaceutical compositions containing ondanseteron and sorbitol as sweetener

摘要

PCT No. PCT/IB95/01152 Sec. 371 Date Jul. 9, 1997 Sec. 102(e) Date Jul. 9, 1997 PCT Filed Nov. 20, 1995 PCT Pub. No. WO96/15786 PCT Pub. Date May 30, 1996The invention relates to a liquid composition for oral administration comprising ondansetron or a pharmaceutically acceptable derivative thereof, a sweetener and one or more pharmaceutically acceptable excipients. The sweetener comprises one or more polyhydric alcohols and the pH of the combination lies in the range 2.0 to 5.0. Methods for the manufacture of such compositions and for their use in the treatment of conditions mediated through the action of 5-hydroxytryptamine (5 HT) at 5 HT3 receptors are also included.