EXTRACTS OF SHARK CARTILAGE HAVING ANTI- COLLAGENOLYTIC, ANTI- INFLAMMATORY, ANTI- ANGIOGENIC AND ANTI- TUMORAL ACTIVITIES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

摘要

A process for the obtention of a liquid extract of cartilage having a substantial portion of the biologically active hydrosoluble components present in intact cartilage, which comprises the following steps: (a) homogenizing the cartilage in an aqueous solution in condition compatible with the preservation of the integrity of said biologically active components until the cartilage is reduced to particles whose size is lower than or equal to about 500 em resulting in a mixture of particles and of a crude liquid extract having said biologically active components; (b) centrifuging said homogenate to separate particles from the crude liquid extract; and (c) further separating the crude liquid extract so as to obtain a final liquid extract containing cartilage molecules having a molecular weight lower than or equal to about 500 kilodaltons (KDa). 673 י" ב באב התש" ס - August 13, 2000