Carbamiloxi compound that inhibit leukocyte adhesion mediated by vla-4, compounds that are prodrugs of the compounds, composicionfarmaceutica,Method for setting vla-4 in a Biological Sample, method for treating an inflammatory condition.

摘要

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases m a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.