Carbamiloxi compound that inhibit leukocyte adhesion mediated by vla-4, compounds that are prodrugs of the compounds, composicionfarmaceutica,Method for setting vla-4 in a Biological Sample, method for treating an inflammatory condition.

摘要

The compound described is VLA-4. Some of these compounds also inhibit leukocyte binders, particularly as measured by VLA-4. These compounds can be used in the treatment of human and other mammalian inflammation, such as asthma, Alzheimer's disease, anorexia, AIDS dementia, diabetes, intestinal inflammation, rheumatoid arthritis.Tissue transplantation, tumor metastasis and thoracic ischemia. These compounds can also be used to treat inflammation of the brain, such as multiple sclerosis. The compound can be a formula in which R1 is selected from a group, including asphalt, alternative asphalt, arilo, alternative arilo, cyclopentadiene, alternative cyclopentadiene, heterocycle, alternative hetereocycleo, isomerization and isomerization; R2 is selected from a group, including hydrogen, tar. Cyclopentyl, cyclopentyl, cyclopentyl, cyclopentyl, cyclopentylArilo, substituting arilo, heteromorphic, substituting heteromorphic, R1 and R2 together with nitrogenound atom to R2 yel S0 (2) group,In combination with R1, they can form an isomerization group or an alternative heterocycle group; R3 is selected from a group, including hydrogen, tar, alternative tar, cyclopropyl, alternative cyclopropyl, alternative arilo, isomerization, alternative isomerization, and alternative. When R2 does not form a heterocycle group containing R1, R2 and R3, the alternative heterocycle. R5 es - (CH2) x-ar-r5, wherein R5 is selected from the group consisting of - o-z-nr8r8 and - o-z-r12 in lacual R8 and R8, independent of the hydrogen tar group.Replaced tar, rotary, rotary, acyclic, substituted