IDENTIFICATION OF NOVEL SPLICE VARIANTS OF THE HUMAN CATALYTIC SUBUNIT Cβ OF cAMP-DEPENDENT PROTEIN KINASE AND THE USE THEREOF

摘要

The Cbeta gene encodes at least 6 different gene products, designated Cbeta1, Cbeta2, Cbeta3, Cbeta4, Cbeta4ab and Cbeta4abc. As is the case with the murine and bovine splice variants, all the human Cbeta splice variants vary in the N-terminal part preceding the part encoded by exon 2. Homologues to all Cbeta splice variants identified in mouse and bovine were identified in human (Cbeta1, Cbeta2, Cbeta3 and Cbeta4) in addition to two novel Cbeta splice variants (Cbeta4ab and Cbeta4abc), that have previously not been identified in any other species. Genomic DNA- and cDNA sequences encode splice variants and include the nucleotide sequences shown in SEQ ID NO: 1, 2, 3, 4, 5 and 6 respectively. The proteins are new splice variants of the Cbeta protein.