Identification of novel splice variants of the human catalytic subunit cbeta of camp-dependent protein kinase and the use thereof

摘要

The C gene encodes at least 6 different gene products, designated C1, C2, C3, C4, C4ab and C4abc. As is the case with the murine and bovine splice variants, all the human C splice variants vary in the N-terminal part preceding the part encoded by exon 2. Homologues to all C splice variants identified in mouse and bovine were identified in human (C1, C2, C3 and C4) in addition to two novel C splice variants (C4ab and C4abc), that have previously not been identified in any other species. Genomic DNA- and cDNA sequences encode splice variants and include the nucleotide sequences shown in SEQ ID NO: 1, 2, 3, 4, 5 and 6 respectively. The proteins are new splice variants of the C protein.