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Radiopharmaceutical peptide containing Rhenium and technetium and methods for producing them containing receptor binding vasoactive intestinal peptides
Radiopharmaceutical peptide containing Rhenium and technetium and methods for producing them containing receptor binding vasoactive intestinal peptides
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机译:含有R和tech的放射性药物肽及其制备方法,其含有受体结合血管活性肠肽
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摘要
A reagent for preparing a radiopharmaceutical consists of a synthetic, receptor binding vasoactive intestinal peptide (VIP) that is covalently linked to chelating moiety capable of chelating a radiolabel such as rhenium or technetium. The chelating moiety is incorporated into the reagent during synthesis of the reagent. The technetium or rhenium labeled radio pharmaceutical has vasoactive intestinal peptide receptor binding affinity that is not less than about one tenth the affinity of radio-iodinated native vasoactive intestinal peptide.
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