3-(4-Substituted piperidinyl-1)-1-(3,4-dichlorophenyl)propyl carbamates and ureas and derivatives as neurokinin receptor (NK1 and NK2) antagonists

摘要

Piperidine compounds, 3-(4-subst.-piperidinyl-1)-1-(3, 4-dichlorophenyl)propyl carbamates and ureas as defined in the specification, their N-oxides, and their pharmaceutically acceptable salts, useful for the treatment of asthma and related conditions. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of the above formula and its intermediates. The piperidine derivatives antagonize the pharmacological actions of the endogenous neuropeptide tachykinins such as SP, neurokinin A (NKA) and neurokinin b (NKB), more specifically, neurokinin 1 (NK1) and neurokinin 2 (NK2).