Substituted 1,3-benzodioxoles and use as antidiabetic, antihyperglycemic, and antiobesity agents

摘要

These compounds, which have anti-diabetic and/or antihyperglycemia and/or anti-obesity activity, have the formula (II), where: R1 and R6 are independently hydrogen, alkyl, trifluoromethyl, cyano, alkoxy, or halogen; R2 is hydrogen or trialkylsilyl; R3 is hydrogen or alkoxycarbonyl; or R2 and R3 are joined to form a ring (a): where R' is hydrogen, alkyl or aryl; R4 and R5 are independently hydrogen or alkyl; R7 and R8 are independently OR9 or NR10R11; R9 is hydrogen, alkyl, cycloalkyl, silylalkyl, aryl, arylakyl, alkoxyalkyl, heteroaryl, -CHR12COOR13, -CHR12C(O)R13, -CHR12CONR10R11, -CHR12OCOOR13, or -CHR12OC(O)R13, with the provision that R9 is not hydrogen in both R7 and R8; R10 and R11 are independently hydrogen, alkyl, aralkyl, aryl, furanylalkyl, or alkoxycarbonylalkyl; R12 and R13 are independently hydrogen, alkyl, aryl, or aralkyl; and their pharmaceutically acceptable salts thereof, the enantiomers thereof, the racemic mixtures thereof, and the diastereomeric mixtures thereof.