Viral peptides with structural homology to protein G of respiratory syncytial virus

摘要

The compounds have structural homology to a contiguous sequence of amino acids within the sequence representing residues 149-197 of the G protein of respiratory syncytial virus wherein: a) no oligosaccharide is linked to potential serine, threonine or asparagine attachment sites; b) four cysteine residues are involved in 10 disulphide linkages and c) the pattern of disulphide linkage is Cys 173 linked to Cys 186, and Cys 176 linked to Cys 182, and in which said compounds possess a biological activity of respiratory syncytial virus G protein. Also disclosed are the antibodies thereto and a pharmaceutical composition thereof useful in treating Pneumovirus infections, especially respiratory syncytial virus.