1,5-dihydro-pyrazolo3,4-d-pyrimidinone derivatives in particular for the treatment of cardiovascular and cerebrovascular diseases, diseases of the peripheral vessels and diseases of the urogenital system

摘要

1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives (Formula I) which are produced by condensing the pyrimidone heterocycle on the appropriately substituted pyrazoles. The compounds are suitable as active substances in medicaments, especially in medicaments used to treat cardiovascular and cerebrovascular diseases, peripheral vascular diseases and diseases of the urogenital tract. Wherein; A and D together represent a radical of the Formula II, wherein R2 represents C6-10aryl which is optionally trisubstituted by identical or different substituents from the series consisting of nitro, cyano, trifluoromethyl, hydroxyl, halogen, carboxyl, or by straight-chain or branched acyl, alkoxy or alkoxycarbonyl; R1 represents straight chain or branched C1-4acyl or C1-10alkyl optionally substituted by hydroxyl, azido or Formula -NR3R4 or -OSO2R5; E represents straight or branched C1-10alkylene optionally substituted by hydroxyl or C=O group; L and V are identical or different and represent C6-10aryl or 5- to 7-membered aromatic; T represents a radical of the formula -CH2-X-Y-, where X represents a bond or an oxygen or sulphur atom or the -NH-group, Y represents a straight-chain or branched alkylene chain having up to 9 carbon atoms;