2 - oxo - imidazolidine derivatives as Integrin Receptor Antagonists avß3

摘要

Refers to a compound I, the Atoms of the double Bond are replaced with R11 and R12; "X" is - C (= nr1r2 NR1) -, - C (= NR1 NR2) - nr1r2, aromatic Ring of 5 or 6 members with 0 - 4 n, or,S; polycyclic Ring 9 - 14 members with 0 - 4 n or s; "and" is - (CH2) M - (CH2) - M - O - N - (CH2), - (CH2) - N - (CH2) mnr4, among others; "Z" is Ring mono or polycyclic with 0 - 4 n, or,S; any methylene "and" not have R4 can be replaced with 1 - 2 R3; R1 and R2 are h, halogen, c1-c4 alkyl, among others; R3 is H, alkyl aryl, C1 - C10, among others, R4 is H, aryl,Aminocarbonilo, among others; R5 and R6 are C1 - C6 h, alkyl, aryl, among others; R7 and R8 is C1 - C6 h, alkyl, aryl, among others; R9 is H, alkyl C1 C8, R10, R11, R12 and R13 is H, alkyl C1 C8Aryl, among others; M and N are 0 - 6; V is 0 - 2. A Preferred Compound is acid 3 (S) - (2,3 dihydro - benzofuran - 6 - yl) - 3 - (2 - oxo - 3 - [3 - (5,6,7,8-tetrahydro - [1,8] naftiridin thiocyanatoacetate} - propionic acid, among others.It also relates to a process for Preparation.Compound I is ovu00df3 Integrin receptor antagonist, ovu00df5, ovu00df6 and is useful to inhibit bone resorption, Treatment and Prevention of Osteoporosis, inhibition of vascular restenosis.Diabetic Retinopathy, Macular Degeneration, inflammation, atherosclerosis, angiogenesis, Wound Healing, viral disease, tumour Growth, metastasis