Method for treating COPD (chronic obstructive pulmonary disease)

摘要

Refers to the use of the compound I, R1 is - (cr4r5) ncoo (cr4r5 MR6), - (cr4r5) nconr4 (cr4r5 MR6, among others); M is 0 - 2; n is 1 - 4; R4 and R5 are h, c1-c2; R6 is H, Methyl, Oh, among others,When R6 is Oh, M is 2; when tetrahidropiranilo R6 - 2, 2 - tetrahidrotiopiranilo, among others, M is 1 - 2; when n is 1, M is 0; R6 is not H - (cr4r5) not (cr4r5) Yr2 MR6; X is Halo, Nitro,Among others, and is o, s or m `; M is 0 - 2; x2 or X3, nr8; X is H or a Group; x4, X5 is H B, R9, 0R8, among others; R2 is - CH3 and - CH2CH3; s is 0 - 4; R3 is H, c1-c4 alkyl, haloAmong others; Z is Cy 'cy' nr10r14 R14, among others; and 'is o or s; R7 is - (cr4r5) qr12, c1-c6 alkyl; Q is 0 - 2; R12 is cycloalkyl C3 - C7, 2 - piridilo, R8 is H, among others;R9 is c1-c4 alkyl; R9, R10 and R11 is 0R8; R11 is H, c1-c4 alkyl; oxazolilo is oxazolidinilo R13, R14, among others; and R7 is h; when are nr10r14 R10 and R14,Together with N form a Ring of five to Seven members, where R12 is pirazolilo N -, N - imidazolilo, among others; Q is not 1.A Preferred Compound is cis - [acid 4-cyano-4 - (cyclopentyloxy 3 - (4-methoxyphenyl) cyclohexane - 1 - carboxylic acid], among others.Compound i Inhibits chemotaxis and degranulation of neutrophils and may be useful for the treatment of chronic obstructive pulmonary disease (COPD)