Polypeptide comprising at least two Link Antigen immunoglobulin domains that bind to the chemokine receptor CXCR2; method to treat chronic obstructive pulmonary disease (COPD) or exacerbations of COPD.

摘要

The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.