APPLICATION OF FXR, PPARALPHA AND LXRALPHA ACTIVATORS IN ORDER TO RESTORE THE BARRIER FUNCTION, TO STIMULATE EPITHELIUM DIFFERENTATION AND TO INHIBIT PROLIFERATION

摘要

Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor alpha, and oxysterol activators of the LXRalpha receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.