METHOD FOR RESTORING P53-DEPENDENT TRANS-ACTIVATING ACTIVITY IN CELLS, ANTI-P53 SINGLE-CHAIN ANTIBODY FRAGMENTS AND DNA ENCODING THEM, THEIR USE AND MEANS CONTAINING THEM

摘要

The invention concerns single-chain antibodies directed against the p53 protein, capable of being expressed in tumoral cells, capable of restoring a DNA binding in vitro and a transcription activator function in vivo. The invention also concerns nucleic acids coding for these molecules, the vectors containing them and their uses.