THE USE OF GLYCERINE TO MODERATE THE TRANSDERMAL CONTRIBUTION OF MEDICINES.

摘要

A TRANSDERMAL / TRANSMUCOSAL DRUG DISTRIBUTION SYSTEM USES GLYCERINE TO MODERATE THE INITIAL EXPLOSION EFFECT OF THE TRANSDERMAL DRUG DISTRIBUTION AND ALSO MAINTAIN THE DISTRIBUTION TO THE DERMIS / MUCOSA IN A PROVISION OF THE APPLICATION DURING THE APPLICATION OF THE APPLICATION OR AFFECTED. THE DRUG COMPOSITION CONTAINS AN EFFECTIVE AMOUNT OF A PERCUTANEOUSLY ABSORBABLE DRUG AND A QUANTITY OF GLYCERINE THAT IS EFFECTIVE TO MODERATE AND MAINTAIN THE DRUG TRANSDERMAL DISTRIBUTION. THE SYSTEM ALSO CONTAINS MEANS TO MAINTAIN DRUG COMPOSITION IN A DRUG TRANSFER RELATIONSHIP WITH DERMIS / MUCOSA. WHEN IT IS APPLIED TO AN AFFECTED PLACE THE APPLICATION IS PREFERIBLY A GEL, CREAM, LOTION OR POMADA. WHEN APPLIED TO AN APPLICATION PLACE THE COMPOSITIONS ARE CONTAINED WITHIN A DEVICE SUCH AS A MATRIX OR LIQUID DEPOSIT PIECE THAT IS PAID AT THE PLACE OF APPLICATION THROUGH THE ADHESIVE. THE DRUG COMPOSITION MUST CONTAIN GLYCERINE IN AMOUNTS BETWEEN 0.1 TO 50% OF THE VOLUME.