O-SUBSTITUTED HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS

摘要

New compounds of formula I(see formula I)wherein:- R and R1 are independently selected from hydrogen, (C1-C6)alkyl, styryl and(C3-C6)cycloalkyl or, taken together with the carbon to which they are linked,form a(C3-C6)cycloalkyl group;- A is selected from the following groups:-CH2C~CCH2-, (see formula II), (see formula III) or -(CH2)q NH-(CH2)q-,wherein q is an integer from 2 to 3- B is selected from(see formula IV); (see formula V); (see formula VI)(see formula VII); (see formula VIII)- T is selected from -CH2-C~CH, -C~CH, -(CH2)p-R3, -CH=CH-R3,-CH2-NHCO-R3, -(CH2)p-O-R3, -CH(NH2)-CH2R3, in which p is 0 or an integerfrom 1 to 4,- R3 is a carbocyclic or heterocyclic ring as medicaments having antitumorand/orantimetastatic activities.