PORCINE SPINAL CORD CELLS AND THEIR USE IN SPINAL CORD REPAIR

摘要

Describe pig cord cell and the method using spinal cord injury caused by cell therapy neurodegeneration as caused by spinal cord injury and neurodegenerative disease. Pig cord cell is preferably from the fetal spinal cord cell for selecting pregnant day to obtain. Pig cord cell can be modified, to be suitble to be transplanted to xenogenesis theme, such as people. For example, can modify pig cord cell, to change the antigen (for example, MHC I classes antigen) for the immune response that can stimulate the cell for xenogenesis subject on cell surface. By contacting with anti-MHC I classes antibody or its segment or derivative, inhibit the rejection of cell when introducing subject. In one embodiment, pig cord cell is obtained from pig, pig cord cell substantially free of can by infection or transmission organism or substance to recipient. Pig cord cell of the invention can treat the spinal cord injury due to caused by the neurodegeneration in xenogenesis subject (for example, the people for suffering from spinal cord injury, amyotrophic lateral sclerosis or multiple sclerosis) spinal cord by the way that cell is imported spinal cord. The umbilical cord of subject.